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Interestingly, mediation analysis showed that TMAOs adverse effect on kidney function strengthened at more severe stages of cardiometabolic disease, implying TMAO synergy with existing pathology (thereby providing 2-hit model)

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Adenovirus-mediated expression of CYP2E1 produces liver toxicity in mice

In peripheral tissues, it helps in -oxidation by transporting medium and long chain fatty acids into the mitochondria [30]

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