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It is a moot point for me as I do not methylate B12 well without self testing for that reality

Our patient was diagnosed with severe GSSD after neonatal onset, with symptoms including hemolytic anemia, hyperbilirubinemia and severe metabolic acidosis (intractable), urine-organic acid analysis results suggestive of the presence of 5-oxoprolinuria, and imaging results suggestive of central nervous system damage and developmental retardation in the infant at follow-up

It is used to stabilize formulas, add thickness, and as a colorant

Saudi J Biol Sci

These studies revealed the beneficial effects of AOX supplementation in men with (a) abnormal semen quality, (b) varicocele, and (c) idiopathic or unexplained infertility (66)

After adolescence, the blood vessels that once supplied nutrients to the disc largely disappear