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The PPP generates NADPH by its rate-limiting enzyme, the 6-phosphate dehydrogenase (G6PDH) and also by the 6-phospho gluconate dehydrogenase
Safety outcomes comprised acute kidney injury (AKI), severe hypoglycemia, treatment discontinuation due to adverse events, expanded major adverse cardiovascular events (MACE), and all-cause mortality
Going too long can make the next meal worse
Always start low, increase gradually, and maintain the dose once desired effects are achieved
paying for a fraction of the full dosage can be a way of staying on it longer, albeit at a lower effectiveness
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