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Urolithin A (UA) attenuates ferroptosis in LPS-induced acute lung injury in mice by upregulating Keap1-Nrf2/HO-1 signaling pathway

indeed, in vitro, treatment of peritoneal macrophages with cholesteryl crystals, which are lipid species commonly found in the blood of dysmetabolic patients, induces the nuclear translocation of TFEB and consequent induction of a panel of lysosomal and autophagy-related TFEB gene targets, including LAL (27)

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