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Semaglutide has a half-life of approximately one week, meaning its effects wane over several weeks, with most of the drug cleared by about 4-5 weeks

The math is simple division, but the implications are significant for planning, budgeting, and storage timelines

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Some individuals lost as much as 20% with consistent use and lifestyle adjustments

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For GLP-1 users, that perspective matters, since progress can be uneven