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Those with a history of pancreatitis should be especially cautious with high-fat foods and report any severe abdominal pain immediately

Celastrol specifically targets the later stages of fat cell development, decreasing fat accumulation by downregulating genes involved in fat cell formation, thus highlighting its potential as a pharmacological strategy in obesity management [26, 49]

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Gastric electrical stimulation (the Enterra device) is FDA-approved under humanitarian device exemption but shows mixed results in clinical trials (McCallum et al., Gastroenterology, 2010)