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It noted that the inventive concept enhancing the half-life of GLP-1 analogues was already disclosed in Novos earlier Genus Patent (IN964)
Naiki-Ito A, Asamoto M, Hokaiwado N, Takahashi S, Yamashita H, Tsuda H, Ogawa K, Shirai T
Other recognised side effects include injection site reactions (redness, itching, or bruising), headache, dizziness, and fatigue
No serious cardiac events were reported at elevated rates
Samples with PPIB ISH scores of 2 (noted as positive) and dapB ISH scores of 0 (noted as negative) were considered to have adequate tissue viability, and GIPR and GLP-1R mRNA ISH were evaluated
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