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Platinum-related anemia Anemia is an important synergistic risk factor for CRF, and platinum can mediates anemia through two major pathways: first, cisplatin and carboplatin have strong myelotoxicity, which can directly damage bone marrow erythroid progenitor cells, inhibit their proliferation and differentiation, leading to decreased erythropoiesis (Bryer and Henry 2018)

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& Konopka, J