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Aside from dose, timing may also influence carnitine's effects since some data suggests it has a beneficial effect when taken before exercise but this isn't always the case depending on the person's baseline serum carnitine levels, with lower levels requiring longer supplementation periods to elicit exercise performance benefits
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A recent meta-analysis study reviewed twelve randomized controlled trials (RCTs) (n = 791) and found that ALC supplementation significantly reduced depressive symptoms in MDD as monotherapy and augmentation compared to placebo, with effect sizes comparable to standard antidepressants and a superior safety profile
K., Ballou, D
