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That's not a minor inefficiencyit's the difference between a 2mg effective dose and a 1015mg required dose to achieve the same plasma concentration

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Other widely used pain/inflammation drugs include gabapentin (for nerve pain) and corticosteroids like prednisone

Risk of cardiovascular outcomes in patients with type 2 diabetes after addition of SGLT2 inhibitors versus sulfonylureas to baseline GLP-1RA therapy