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Retatrutide's proposed mechanism of action involves GLP-1 receptor activation to slow gastric emptying and promote satiety, GIP receptor activation to support insulin secretion and adipose tissue regulation, and glucagon receptor agonism, which in trial settings has been associated with increased energy expenditure and lipolysis

Since then, several GLP-1s for obesity have been approved for new indications, such as secondary cardiovascular risk reduction (Wegovy), sleep apnea (Zepbound) and metabolic dysfunction-associated steatohepatitis, or MASH (Wegovy)

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