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The new 5-HT hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

Insulin signaling pathway and related molecules: Role in neurodegeneration and Alzheimers disease

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10.1016/j.bioorg.2020.103718 55 LiuY.XuY.LiM.PanD.LiY.WangY.et al (2020)

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Thus far, the binding poses of two full-length peptide-bound, active GLP-1R structures 3,4 and an active-like structure with a truncated peptide agonist (peptide 5) 12 have been detailed, as well as variable ligand-dependent ECD receptor conformations