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Most people start at a low dose and increase slowly to minimize potential side effects (like nausea or stomach upset)

It's incredibly stable in this form

In vivo metabolic research employs diet-induced obesity mouse models (DIO C57BL/6) or genetic diabetic models (db/db, ob/ob) with controlled sema dosing and comprehensive metabolic phenotyping including indirect calorimetry, glucose and insulin tolerance tests, body composition by NMR or DXA, and tissue-level molecular profiling of liver, fat, and muscle samples

Free Radic Biol Med 40:21552165

Starting dose also mattered for tolerability

You cant have your cake and eat it, too.