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Intrapelvic injection of GLP-1 with direct recording of afferent renal nerve activity (ARNA) Rats were anesthetized with urethane (0.75 g/kg, i.p.) and -chloralose (70 mg/kg, i.p.)

Clinicians must remain cautious: GLP-1 RAs are not fertility treatments and should be discontinued before conception until safety data are robust

Es un anlogo cclico sinttico de la hormona -MSH (heptapptido, CAS 121062-08-6) y agonista no selectivo de los receptores de melanocortina MC1R-MC5R

GLP-1-driven weight loss works more slowly and less dramatically, but it treats the cause rather than overriding it, and it tends to improve testosterone and semen quality instead of suppressing them

Time to progression to dementia was also unaffected

As more patients are started on GLP-1 analogues, optometrists should be aware of the frequency of potential worsening retinopathy that occurs with rapid, improved glycemic control