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In clinical trials where a GLP-1 RA was added to background basal insulin, a general 20% basal insulin reduction in all patients or a 20% reduction in patients with an A1C 8.0%, the GLP-1 RA can be reasonably initiated without a reduction in the basal insulin dose for many patients
Review the multi-society statement summarized by the American Society of Anesthesiologists with your surgeon/anesthesiologist
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If you experience intolerable side effects with standard doses, customized microdoses of compounded semaglutide may help achieve desired results with minimal side effects
Novo also admitted that users of semaglutide may have to remain on the treatment
Beyond emergency situations, you should also reach out to your prescribing healthcare professional if your adjustment symptoms are significantly impacting your quality of life or ability to function normally after the first two weeks, if you are unable to maintain adequate nutrition or hydration, if you develop new symptoms that were not discussed when you started the medication, or if you have concerns about whether the medication is working as expected
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