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To counteract this and make the drug effective for a longer time, inhibitor molecules like that in PDB entry 3gss can be administered along with the drug to inhibit the action of the enzymes
However, when excessive amounts of acetaminophen are ingested, the livers supply of glutathione can be depleted rapidly, leaving NAPQI unneutralized.[ref] Glutathione is the master antioxidant, but there are several situations in which glutathione levels may already be low and thus unable to rise to the occasion for high doses of acetaminophen
Accession codes Accessions Gene Expression Omnibus References Hayes, J
A Phase 2 trial for HIV-associated lipodystrophy was discontinued in 2006-2007 after a participant death, and development was never resumed
