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Signals only observed in the setting of short duration of exposure would be highly suggestive of reverse causality

Metabolic Safety: IGF-1 and Glucose Effects One of the most clinically significant safety findings relates to AOD-9604s metabolic profile, particularly its lack of effects on insulin-like growth factor-1 (IGF-1) and glucose metabolism

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doi:10.1080/00016340902859315

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10.1016/j.cmet.2015.05.006 Cell Metab