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Yet, the short duration of the study did not permit a conclusion on whether the lowering of homocysteine through B-vitamin supplementation could have long-term benefits on bone strength and fracture risk (119)

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nicotine, methyl vinyl ketone, and ,-unsaturated aldehydes, such as, acrolein and crotonaldehyde) could be responsible for NOX-mediated oxidative stress [10]

Human clinical trial data remains limited, with Phase I and II trials for inflammatory bowel disease conducted in the 1990s claiming safety with no toxicity, though full peer-reviewed data never appeared in scientific literature

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