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The ensuing mechanistic study revealed that ebselen protected cells and mice models by lowering radiation-induced ROS production, followed by inhibition of lipid peroxidation, protein carbonylation, DNA damage, and ultimately apoptosis

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However, at endpoint Z, mRNA levels of CCL2 , CXCL9 , IL6 , IL17A , CCL1 and TNF were lower in the MOD and/or SEV groups compared to the controls, probably due to previous glucocorticoid treatment that patients received during hospitalization

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