This nanoparticle can be passively targeted into the mouse model of acute renal injury caused by sepsis with enhanced vascular permeability, and can passively target renal inflammatory injury to the vascular endothelium, protect the mitochondrial structure, and reduce the apoptosis and necrosis of renal tubular cells by reducing the oxidative stress and inflammatory reaction (Yu et al., 2020)
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Eight-week-old male C57BL/6J mice and LDLR / global knockout mice were purchased from Beijing Huafukang Biotechnology Co., Ltd