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GIP has been shown to decrease food intake while blunting the metabolic adaptive responses that usually occur with calorie restriction resulting in weight reductions, and when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose and lipids

tirzepatide remains the primary driver, with carnitine as an optimizing adjunct

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Some versions use 1.1% benzyl alcohol