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These symptoms can lead to reduced food intake and fluid/electrolyte losses, both of which contribute to feelings of weakness
doi:10.1097/ADM.0000000000000992 Skinner MD, Lahmek P, Pham H, Aubin HJ
Clinically, GLP-1s are generally safe when prescribed and monitored properly, but they can cause side effects such as nausea, vomiting, and gastrointestinal discomfort, especially when people first start treatment
What is Retatrutide used for
Understanding this can help you set realistic expectations
A 2025 body-composition substudy added detail on fat-mass versus lean-mass changes within the T2D Phase 2 cohort fat mass accounted for the majority of total weight reduction (PMID 40609566)
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