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Given the functional synergy and complementary mechanisms between GLP-1R and GIPR, therapies targeting both GIPR and GLP-1R activation have emerged as promising approaches for obesity and type 2 diabetes treatment to improve weight loss and metabolic outcomes

Future research should focus on optimizing the dose, bioavailability, and long-term effects of C3G, and exploring its interaction with gut microbiota to pave the way for novel dietary or pharmacological strategies enhancing metabolic health in T2DM

The detection time of a peptide depends not just on how long it remains active , but also on how long its metabolites or molecular fingerprints can be identified in blood, urine, or tissue samples

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