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For active individuals, an annual cardiovascular review that includes exercise tolerance assessment adds a useful data point

When 50 Pounds Is a Stretch Goal For patients starting below 240 pounds, losing 50 pounds represents more than 20% of body weight, which puts it in the upper range of what these medications typically produce

Leombruni P, Miniotti M, Colonna F, Sica C, Castelli L, Bruzzone M, Parisi S, Fusaro E, Sarzi-Puttini P, Atzeni F, Torta RG

Tucker M, Keely A, Park JY, et al

Its an incredibly strong stimulant, and users may become attached to the feelings and focus they experience when they take the drug