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They have different mechanisms to influence organ-specific tropism via different signaling pathways, such as the chemokine pathway CXCL12/CXCR4 (161), integrin-mediated adhesion (163), and changes in the ECM and tumor cell extracellular vesicles to establish a pre-metastatic microenvironment (164, 165)

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doi: 10.1016/j.cell.2017.11.001 87 AliRAWuescherLMDonaKRWorthRG