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Longer cycles (12+ weeks) may require extended washout periods (68 weeks) to fully reset metabolic pathways
Further, NASO B12 was well-tolerated throughout the treatment period.[] Patients on metformin therapy receiving NASO B12 should also be instructed that they will require weekly intranasal administration of NASO B12 spray in each nostril after correction of vitamin B12 deficiency for the remainder of their lives
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Importantly, lipotropic combination injections are generally unlicensed in the UK and, if used, must be supplied as MHRA-regulated 'specials' on prescription from licensed manufacturers or importers
This can help prevent B12 deficiency from long-term use of H2 blockers
Loading phase (with neurological symptoms): 1mg on alternate days until there is no further improvement, then every two months
