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These include the bell-shaped dose-response curve, central effects after peripheral administration, a delayed and prolonged time course, and some penetration of the blood-brain barrier in essentially intact form
pylori infection induces ARG2 expression, potentially leading to L-arginine depletion and reducing NO-dependent bactericidal activity (Lewis et al., 2010)
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In addition, binding of tryptophan metabolites to aromatic hydrocarbon receptors can counteract signals that activate T cells, leading to immune escape by tumor cells 36,37
Inhibition of aak1 kinase as a novel therapeutic approach to treat neuropathic pain
Hepatology 53 , 945953, doi: 10.1002/hep.24104 (2011)
