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Tirzepatide can be combined with insulin, but insulin doses typically require reduction to prevent dangerously low blood sugar

Tirzepatide is not indicated for type 1 diabetes and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

P values were calculated using a two-tailed Students t-test ( g ) one-way ANOVA ( b, d, e, i )

Naltrexone is the generic name of the medication, while Vivitrol is a brand-name, extended-release version

Author contributions D-DW, S-MH, PZ, and Q-LW conceived and designed the study

Most evidence preclinical