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doi: 10.1177/20420188221102800

Because the body's stress response runs through the hypothalamic-pituitary-adrenal axis, support that helps the brain stay clear under pressure may make that response feel more manageable, a stress cascade described in detail by Harvard Health Publishing

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A 2024 randomised trial in adults with elevated fracture risk found that semaglutide reduced hip bone mineral density by 2.6% and lumbar spine density by 2.1% at 52 weeks compared with placebo