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mild side effects include nausea, diarrhea (oral), or temporary fishy body odor at high doses

This isn't dangerous, but intradermal administration produces erratic absorption and localized irritation because the dermis lacks the vascular and lymphatic network that governs SubQ pharmacokinetics

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Injection site reactions are the most common local side effect of semaglutide

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An oral antihistamine like cetirizine or loratadine, taken 30 to 60 minutes before injection, can prevent or reduce reactions for people who consistently experience them