Semaglutide trials reported 24-29% constipation rates while tirzepatide trials showed 12-27%
Microdosing therefore sits between plausible mechanism and proven outcomes
Here are two notable studies that outline the GH-increasing effects of both CJC-1295 and ipamorelin: CJC-1295 administered as a subcutaneous injection to healthy study volunteers resulted in an increase in overall GH levels while maintaining GH pulsatility, with peak levels staying within normal ranges
For example, if you are prone to vitamin D deficiency, increasing your vitamin D intake might be more beneficial than it would be for someone with adequate levels
The carnitine pool also influences the neuroendocrine system
Glucagon-like peptide-1 (GLP-1) receptor agonistsincluding semaglutide (Ozempic, Wegovy), dulaglutide (Trulicity), and liraglutide (Victoza, Saxenda)work by mimicking the incretin hormone GLP-1