CMT is a temperature-dependent and saturated process following MichaelisMenten kinetics, which can be affected by various types of inhibitors, which include competitive (competing for transport-active binding site), non-competitive (modulating substrate binding allosterically), uncompetitive (hampering the modification of the substrate-transporter complex conformation) or mixed-type inhibitors (47)
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10.1016/j.smrv.2016.06.009 95 RiquelmeE.ZhangY.ZhangL.MontielM.ZoltanM.DongW.et al (2019)
The application includes the drugs liraglutide, dulaglutide, semaglutide, and tirzepatide