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The newly formed synapses induced by Dihexa treatment are functionally active rather than merely structural
10.1016/j.celrep.2017.10.008 230
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On the contrary, PA supplementation led to a reduction in the blue granules, indicating less iron deposition
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But there are several obstacles to the development of this senolytic approach such as the long-term effect of CAR-T cells therapy with possible aspecific toxicity in different organs 56 , the cost and the difficulty during process development 57 or the selection of non-exhausted T cells to generate efficient therapy 58,59
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