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Identification of cell types required for DPP4i to control lipid tolerance
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Jendle, J
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The mechanism of action includes binding to the GHS-R1a receptor, activation of the Gq/11 protein-dependent signaling pathway and an increase in the intracellular concentration of calcium ions in somatotropes
Consistently, the truncated metabolite GLP-2(333) acts as a partial agonist with great reduction in binding affinity and potency
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