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The Phase 2 trial reference point The Phase 2 retatrutide trial (Jastreboff et al., New England Journal of Medicine 2023) enrolled 338 adults across placebo and retatrutide arms at 1, 4, 8, and 12 mg weekly

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Its the only compound in this comparison with active FDA approval granted in 2010 under the brand name Egrifta for reducing excess visceral abdominal fat in HIV-associated lipodystrophy which sets it apart from AOD-9604 and most other peptides discussed alongside it

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