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Elevated amounts of oxidative stressors and inflammatory cytokines are closely associated with pancreatic harm in diabetic laboratory rats

Copper has been revealed as a key regulator in various cell signaling pathways such as membrane receptor-associated pathways and growth factor-associated pathways (Grubman and White, 2014)

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Meanwhile, epigallocatechin gallate (EGCG), used alone or together with GLP-1 agonist exendin-4, was shown to enlarge islet area and number, expand -cell area, and boost pancreatic insulin content in diabetic and obese mouse models, thus demonstrating favorable therapeutic outcomes (Nupur et al., 2018)

PMID: 35408963 | doi:10.3390/ijms23073607 Araj SK et al