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Corticosteroids degrade collagen and thin the dermis with prolonged use

Interestingly, we observed that the cecal microbiome of previously-obese animals returned to the lean state through NNMTi treatment and LD switch was distinct from the cecal microbiome of continuously lean control animals

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Abdominal subcutaneous fat provides easy access for systemic administration

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However, if vitamin B 12 deficiency is the cause, it will persist despite the resolution of the anemia