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Data acquisition was using an Agilent 6546 Q-TOF instrument (ESI) with optimized parameters: gas temp 300 C, drying/sheath gas 8/11 L/min, capillary voltage 3500 V, and spray voltages 500/1000 V

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NFL levels were also lowered suggesting motor neuron protection, and exploratory clinical end points looked favourable in the high-dose arm

The 15mg format is preferred for long-term, high-throughput, or multi-phase studies requiring consistent aliquoting and reduced variability.

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Do not extend the 28-day window to compensate, and do not leave it out again