Tirzepatide, a dual glucagon-like peptide-1 (GIP) and GLP-1RAs, administered once weekly at a 15 mg dose, resulted in an average weight loss of 20.9% over 72 weeks (Jastreboff et al., 2022), driven by its synergistic effects on appetite regulation, energy intake reduction, and fat mass decrease (Heise et al., 2023)
How it works: When liver glycogen is depleted, fatty acids are metabolised to acetyl-CoA, then converted to ketone bodies (acetoacetate, -hydroxybutyrate, acetone)
Consult a healthcare professional before combining it with other supplements
KozlitinaJSmagrisEStenderSNordestgaardBGZhouHHTybjaerg-HansenAet al
While federal law allows the prescription of compounded drugs, they are not FDA-approved and do not undergo safety, effectiveness, or manufacturing review by the FDA
Losing weight often requires dietary changes, and semaglutide users may naturally consume fewer calories because the medication suppresses appetite