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While there have been conflicting reports regarding ROS generation in cells treated with NSAIDs 53 , colon cancer cells reportedly exhibit stronger ROS generation than other cancer cell types 54,55 , which is consistent with the findings of our present study

Rare cases of allergic contact dermatitis have been described with prolonged copper exposure, so persistent or worsening inflammation should prompt discontinuation and medical evaluation

The mechanism explaining this selectivity is straightforward

Renal function: Dehydration secondary to gastrointestinal side effects can impair renal function, particularly in those with pre-existing kidney disease

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