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Once vial is opened and exposed to air/moisture, the entire contents begin degrading

Reconstituted epitalon requires refrigeration at 2 to 8 degrees Celsius and remains stable for approximately 4 to 6 weeks

[8] Although not an absolute contraindication, patients with coronary artery disease or unstable angina should only use B-Complex injections containing niacinamide under physician supervision, since high-dose niacin supplements have been linked to arrhythmias in such patients