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AFB 2007)
SURMONT-5 for weight loss: Wegovy vs
Semaglutide, the active ingredient in medications like Wegovy, Ozempic, and Rybelsus, works by mimicking a naturally occurring hormone in your body called glucagon-like peptide-1 (GLP-1)
If Lilly secures approval for Orforglipron as the first oral weight-loss drug, it could gain a critical edge in the billion-dollar obesity market
TRIUMPH-4 (28.7% weight loss, knee OA population, December 2025), TRIUMPH-1 (28.3%, general obesity, May 2026), TRANSCEND-T2D-1 (-2.0% HbA1c, 16.8% weight loss, June 2026), TRIUMPH-2 (20.8% weight loss, obesity + diabetes, July 23, 2026), and TRIUMPH-3 (22.6% weight loss, obesity + cardiovascular disease, July 23, 2026) have all reported positive results
N Engl J Med (2019) 380:34757
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