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The authors found that GLP-1 RA use was associated with a significantly decreased risk of developing dry AMD compared with patients taking metformin (HR = .68), insulin (HR = .72), and statins (HR = .70)

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Hormonal and metabolic adaptation represents another significant factor

When these receptors are activated, they initiate intracellular signalling pathways that lead to the release of stored GLP-1 from secretory granules within the L-cells

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PMID 33354859