And while I dont think animal studies are worthless, theyre preliminary
New England Journal of Medicine (NEJM), 2023 Phase 2 Trial Results JAMA, 2024 Metabolic Effects of Retatrutide Cell Metabolism, 2024 Triple Agonist Mechanism Review American Diabetes Association (ADA) Scientific Sessions 2023 Eli Lilly Clinical Pipeline Report 2024
The PHOX designation refers to phagocyte oxidase
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References for the retatrutide data: Jastreboff et al., NEJM 2023: Sanyal et al., Nature Medicine 2024: Giblin et al., TRIUMPH rationale, Diabetes Obesity Metabolism 2025: How to Minimize Side Effects and Maximize Comfort GLP-1s can cause nausea, constipation, and appetite suppression