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How Semaglutide Works Semaglutide works in several ways to help people more effectively manage their blood sugar levels and weight: Stimulates insulin secretion: Semaglutide functions like glucagon-like peptide 1 (GLP-1) an incretin hormone to stimulate GLP-1 receptors on cells

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Glucagon-like peptide-1 receptor (GLP-1R), a class B G-protein-coupled receptor (GPCR), is broadly expressed on the surfaces of various cells, including the pancreas, intestine and brain [8]