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A glucose tolerance test requires an individual to drink a sugary fluid and have blood glucose levels measured at regular intervals

The 2023 NEEL gel IRB study reported an average 28% increase in skin collagen density at 3 months

STEP 4, a withdrawal study, demonstrated that weight regained after stopping semaglutide, reinforcing that the drug works best as an ongoing intervention rather than a short course

a low ratio decreases IL-12 secretion which favors a Th2 response pattern over Th1 (a condition typically associated with chronic inflammation), while an elevated ratio favors a Th1 response (Kwon et al., 2019)

Seghal added that the findings are not definitive: "We can't say that GLP-1s are actually causing these symptoms." Copyright 2026 Nexstar Media, Inc