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Lonza) was used for all other KAT6A mutations to increase the rate of HDR, following a modified Alt-R CRISPR-Cas9 System protocol (IDT)

Dex treatment reduced inflammatory cells and Yohimbine (YOH, 1 mg/kg) reversed the protective effects of Dex

The most common are mild and may include nausea, digestive discomfort, or fatigue especially during early dose adjustments

Why this matters: Higher doses slow digestion more aggressively Sudden appetite suppression can shock your system Increases risk of nausea, fatigue, and dizziness What to do: Follow a gradual dosage plan Stay at each dose level until your body adapts Never increase dose just to speed up weight loss Key Insight: Slower progression = fewer side effects + better long-term results 2

For this, a dilution buffer containing 0.3% SDS (w/v) was developed

These actions collectively induced both SAR and ISR in rice, leading to long-term immune protection against plant diseases