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Tirzepatide titration: 2.5mg to 15mg Tirzepatide uses a six-step titration over approximately 20-24 weeks: Weeks 1-4: 2.5mg weekly Weeks 5-8: 5mg weekly Weeks 9-12: 7.5mg weekly Weeks 13-16: 10mg weekly Weeks 17-20: 12.5mg weekly Week 21 onward: 15mg weekly (maximum dose) Not everyone reaches 15mg

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It should not be given to children or teenagers with or recovering from viral illnesses due to Reye's syndrome risk

Methods Materials and reagents The intestinal L cell line STC-1 and islet cell line NIT-1 were obtained from the Chinese Academy of Sciences

ACS Chem Biol (2015) 10(7):16049