Harsh chemicals like hydroquinone, which have been used historically for skin lightening, can cause side effects such as skin irritation, ochronosis (a bluish-black discoloration), and even increased risk of cancer with prolonged use
Room temperature medication flows more smoothly and integrates with tissue more comfortably
Copper-catalyzed oxidation requires molecular oxygen
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International union of Pharmacology
On exfoliation nights, use GHK-Cu without retinol alternate the two on different evenings