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Disulfide bonds are relatively stable under physiological conditions but undergo selective cleavage in the tumor microenvironment (TME), minimizing premature drug release [53]

Interestingly, the weight loss effect of AOD-9604 did not follow the usual "more is better" principle

Not unexpectedly, an iron chelator still protects, but inhibitors targeted against the formation of mitochondrial peroxynitrite or the enhanced scavenging of peroxynitrite are now ineffective [75,81]

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